【摘要】 目的:研究萘丁美酮-β-环糊精包合物的包合工艺,提高萘丁美酮的溶解度和生物利用度。方法:用沉淀法和超声法制备萘丁美酮-β-环糊精包合物。考察包合方法、投料比、温度、时间等因素对包合物制备的影响,以紫外分光光度法对包合物进行含量测定,选出最佳制备工艺。结果:超声法优于沉淀法,萘丁美酮的包合率达93％,最佳包合条件:萘丁美酮:β-环糊精(摩尔比)为1:6;包合时间0.5h;包合温度45℃。萘丁美酮包合物的溶解度是萘丁美酮的5.84倍。结论:以萘丁美酮:β-环糊精力1:6(摩尔比),在45℃超声波包合0.5h工艺最佳。更多还原

【Abstract】 Objective: To prepare the inclusion complex of nabumetone-β-CD for improving its solubility and bioavaibility. Moth-od: The inclusion complex of nabumetone-β-CD was prepared by the precipitation method and the ultrasonic method. The influences of inclusion method, temperature, time, and etc on the preparation of the inclusion complex were explored. The content of the inclusion complex was determined by UV spectrophotometry. Results: The result showed that the ultrasonic method was better than the precipitation method, the nabumetone inclusion rate of nabumetone-β-CD is 93% . The optimal preparing condition: nabumetone: B-CD (mol:mol) = 1 :6 , time required 1h, temperature was 45℃ , the solubilty of the inclusion complex was 5. 84 times of nabumetone. Conclusion: The optimum preparing condtions: A proportion of nabumetone to β-cyclodextrin is 1:6 (molar:molar), inclusion time is 30 rnin, inclusion temperature is 45 ℃ .更多还原