【摘要】 目的 :探讨并建立植入用缓释氟尿嘧啶的人体内血浆浓度经时模型。方法 :分析体内过程 ,建立微分方程 ,求解与证明。结果 :经 19例试验者数据拟合 ,其人体内血药浓度经时模型为 :单室开放式模型 ,血药浓度方程C =A1 e-Ket+A2 e-Kat+A3e-Krt。结论 :此方程为植入剂药代动力学参数的计算提供理论参数。更多还原

【Abstract】 Objective:To discuss and set up plasma concentration time equation of 5 fluorouracil sustained release subcutaneous implant in human.Methods:The in vivo process of the drug was analyzed,and the differential equation was set up.The solution was found.Results:Afte the data of 19 patients were analyzed,the plasma concentration time curve was fitted to one compartment open model.The plasma concentration time equation was C =A 1 e -Ke t +A 2 e -Ka t +A 3 e -Kr t .Conclusion:The plasma concentration time equation may provide the theoretical reference for the calculation of the pharmacokinetic parameters of subcutaneous implant.更多还原