【摘要】 近年来 ,以DNA芯片为代表的生物芯片技术 ,得到了迅猛发展 ,已有多种不同功用的生物芯片问世。目前生物芯片技术已应用于分子生物学、疾病的预防、诊断和治疗、新药开发、司法鉴定和食品卫生监督等诸多领域 ,已成为各国学术界和工业界所瞩目并研究的一个热点。生物芯片技术的飞速发展 ,引起了制药业的极大兴趣 ,使得生物芯片技术在药物研究与开发领域得到越来越广泛的应用 ,已逐渐渗入到药物研发过程中的各个步骤。目前 ,生物芯片技术已经应用于药物靶点发现与药物作用机制研究、超高通量药物筛选、毒理学研究、药物基因组学研究以及药物分析等药物研发环节。可以预见 ,随着生物芯片技术的不断发展 ,生物芯片技术将在药物研究与开发领域 ,尤其是在中药现代化研究中得到更广泛更深入的应用。更多还原

【Abstract】 Biochip is newly developed miniaturized analytical platform for molecular biology and biochemistry. Advances in biochip technology enable massive parallel mining of biological data. In the present age, pharmaceutical industries have great interests to biochip technology because of its huge impact and rapid development. Recently, biochip technology has been applied to almost all fields of drug discovery and development, such as drug target validation, high throughput drug screening, toxicology, pharmacogenomics and drug analysis. It is trusted that with the sustained rapid development of biochip technology, it will be applied more widely and deeply in drug discovery and development, especially in the study of the traditional Chinese medicine.更多还原