【摘要】 目的 :探讨更年期女性非胰岛素依赖型糖尿病 (NIDDM)患者血清性激素变化与微血管并发症的关系。方法 :应用放射免疫法检测了 4 0例 4 0～ 6 0岁更年期女性 NIDDM患者血清雌二醇 (E2 )、睾酮 (T)、卵泡刺激素 (FSH)和黄体生成素 (L H )水平 ,并与 2 6例同年龄段正常更年期妇女进行对比。结果 :NIDDM患者组 E2和 T均较正常的对照组显著降低 (P<0 .0 2和 P<0 .0 5 ) ;NIDDM患者组中伴有微血管并发症者的 E2 和 E2 /T较无微血管并发症者更为降低 (P<0 .0 5和 P<0 .0 2 ) ;而 FSH和 L H在 2组间均无显著性差异 (P均 >0 .0 5 )。结论 :更年期女性 NIDDM患者性激素失调可能是其微血管并发症发生或促成因素之一。更多还原

【Abstract】 Objective:To investigate the relation between serum sex hormone changes and micrangium complications in noninsulin dependent diabetes mellitus(NIDDM) patients during woman climacterium.Methods:The level of serum estradiol (E 2),testosterone (T),folliclestimulating hormone(FSH) and luteinizing hormone(LH) were measured with radioimmunoassay in 40 cases with NIDDM (4060 years old) and 26 cases without NIDDM (control group)in woman climacterium.Results:E 2 and T levels in NIDDM patients were considerably lower than those in the control group ( P <0 02 and P <0 05);and E 2 and E 2/T levels were much lower in the NIDDM patients with micrangium complication than those without micrangium complications ( P <0 05 and P <0 02),while FSH and LH were no difference changes in NIDDM or control groups and had or without micrangium complications.Conclusions:Sex hormone disorder in female NIDDM patients in the climacterium may be one of the factors to induce micrangium complications or to foster it.更多还原