【摘要】 目的 :探讨脾胃湿热证患者血胃泌素、胃动素、生长抑素含量变化及中药自拟方清浊安中汤对其的影响。方法 :选取脾胃湿热证患者 31例 ,服用自拟方清浊安中汤进行治疗 ,以放射免疫法观察血中胃泌素、胃动素和生长抑素水平 ,并与 15例脾气虚证患者及 10例健康志愿者对照。结果 :经过 2～ 3周的治疗 ,93.5 %的脾胃湿热证患者症状完全消失 ;经治疗患者胃泌素、胃动素水平恢复正常 ,脾胃湿热证症状也随之解除。结论 :脾胃湿热证与胃泌素水平的升高有关 ;胃动素可能与脾胃湿热证和脾气虚证的某种共同病理特性有关 :生长抑素与脾胃湿热证的关系尚有待进一步的研究 ;清浊安中汤是治疗脾胃湿热证的良药。更多还原

【Abstract】 Objective: To investigate the influence of Qingzhuo Anzhong decoction (QAD) on gastrin, motilin and somatostatin levels in patients with damp-heat syndrome of spleen-stomach (DHSS). Methods: Forty-six patients were selected and divided into two groups: DHSS group (n=31) and group of spleen-qi deficiency syndrome (SQDS) (n=15). The patients with DHSS were treated with QAD for 2 to 3 weeks, and those with SQDS and 10 healthy volunteers served as controls. Serum samples were taken pre- and post- treatment for measuring gastrin (GAS), motilin (MTL) and somatostatin (SS) levels. Results: The GAS, MTL levels in DHSS group and MTL level in SQDS group were significantly higher than those of normal control group (P< 0.05). There was no statistically difference in SS level among three groups. At the end of the treatment, symptoms in the patients with DHSS disappeared accompanying with the normalization of GAS and MTL. Conclusion: High GAS level might related with the damp-heat syndrome of spleen-stomach. High MTL level might be a common sign of both damp-heat syndrome and spleen-qi deficiency syndrome. QAD is a good formula for DHSS.更多还原