【摘要】 目的:揭示莪术油对小鼠肝癌细胞凋亡的影响。方法:用莪术油进行2次小鼠肝癌体内抑制实验。以细胞原位凋亡TUNEL染色方法,评估莪术油对小鼠肝癌细胞凋亡的影响。结果:莪术油对小鼠肝癌细胞的抑癌率分别为51.85％和51.16％,与对照组相比有显著性差异(P<0.01);经莪术油作用过的小鼠HepA肝癌细胞的原位凋亡指数(AI)为6.64±1.26,与对照组2.32±0.82比较差异有显著性(P<0.01)。结论:莪术油抑制小鼠肝癌生长的机理可能与其诱导肝癌细胞凋亡有关。更多还原

【Abstract】 Objective: To reveal the effect of CAO on the cellular apoptosis of hepatoma carried by mice. Methods: After two inhibitory hepatoma experiments in vitro were conducted, the effect of CAO on cellular apoptosis of hepatoma carried by mice was evaluated by method of TUNEL. Results: The tumor inhibitory rates of CAO were 51.85% and 51.16% in two experimenets, respectively. Compared with those of the control groups, differences were statistically significant (P<0.01). In the group of mice treated with CAO, the index of apoptosis (AI) was 6.64±1.26, which was significantly higher than 2.30 ± 0.82 of the control group (P < 0.01). Conclusion: The inhibition of CAO on the growth of hepatic carcinoma carried by mice might be associated with its inducing cellular apoptosis.更多还原