【摘要】 目的 :研究脑皮质局部应用地塞米松对兔脑外伤后脑水肿和脑组织损害的减轻程度。方法 :2 2只兔随机分为 A(对照组 )和 B(治疗组 ) 2组。应用骨窗成形硬脑膜外打击法制备脑挫裂伤动物模型。B组采用局部微量等距离扩渗法于脑皮质局部损伤灶内注射地塞米松 ;A组以同样方法注射等量生理盐水。以脑组织含水量和血清髓鞘碱性蛋白 (MBP)作为观察指标。结果 :A、B2组兔患侧大脑半球含水量分别为 (81.75± 0 .5 6 ) %和(79.45± 0 .5 2 ) % ,B组显著低于 A组 (P<0 .0 5 )。 A组血清 MBP为 (5 .98± 2 .0 8) μg/L,B组为 (3.15±1.0 9)μg/L ,A、B 2组 MBP均较正常对照值 (1.6 6± 0 .71)μg/L增高 ,但 A组显著高于 B组 (P<0 .0 5 )。结论 :脑挫裂伤后脑含水量和血清 MBP增高 ,治疗后两者均降低 ,说明局部应用地塞米松对脑损伤有明显治疗作用更多还原

【Abstract】 Objective:To study the role of dexamethasone on cerebral edema and brain damage after brain injury by local treatment.Methods:Twentytwo rabbits were radomly divided into 2 groups,group A ( the control group) and B (the treated group).An experimental rabbit model was conducted to contusion by bone windowplasty with extradural hitting.Group B was treated by local infiltrating and spraying of dexamethasone at equidistance to lesions.Group A was given normal saline as the same way.The changes of moisture in brain tissues and serum myelin basic protein(MBP) were observed.Results:The percent of water content in lesioned hemisphere in group A and B were (81 75±0 56)% and (79 45±0 52)% respectively.There was a significant difference between the two groups ( P <0 05).The normal value of MBP was (1 66±0 71)μg/L,while the value of MBP in group A and B were (5 98±2 08)μg/L and (3 15±1 09)μg/L.The value of MBP in group A and B were higher than that in normal state and there was also a significant difference between group A and B ( P <0 05).Conclusions:The brain moisture and MBP in serum were increased after brain injury while reduced after treatment with dexamethasone.It demonstrate that local using of dexamethasone has an obvious therapeutical effect on brain injury.更多还原