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猪乙型脑炎减毒活疫苗的安全性和免疫原性试验

Safety and Immunity Tests of Attenuated Japanese B.Encephalitis Live-vaccine Used for Swine

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【作者】 徐涤平刘泽文杨宜生熊忠良段正赢邵华斌贾丽丽俞永新

【Author】 XU Di-ping1, LIU Ze-wen1, YANG Yi-sheng1, XIONG Zhong-liang1, DUAN Zheng-ying1,SHAO Hua-bin1, JIA Li-li2, YU Yong-xin2(1.Animal Husbandry and veterinary Science institute, Hubei Academy of Agricultural Science, Wuhan, Hubei Province 430209; 2. National I

【机构】 湖北省农业科学院畜牧兽医研究所中国药品生物制品检定所中国药品生物制品检定所 湖北武汉430209湖北武

【摘要】 将猪用JEV减毒株SA14-14-2VS制备的活疫苗脑内注射3周龄小白鼠,不能使小鼠致病。用不同剂量活苗注射后备母猪,均未出现任何不良的临床反应。用后备母猪进行免疫原性试验,能产生良好的免疫应答。免疫该疫苗的初产母猪能抵抗JEV强毒的攻击,不产生病毒血症,对胎儿感染的保护率达100%。因此,该减毒活疫苗具有可靠的安全性,良好的免疫原性。

【Abstract】 The attenuated live-vaccine made from the SA14-14-2VS strain was inoculated into the brains of themice and it didnt make the mice sick and die. The vaccine was safe to the replacement gilts when they wereinoculated with different doses, and the gilts had high immunity response. Primiparous gilts inoculated with thevaccine could resist the high pathogenic JEVs attack, and their foetus were all protected. The vaccine was safeand had good immunity.

【关键词】 猪乙型脑炎减毒活疫苗安全性免疫效力
【Key words】 JEVattenuated live-vaccinesafetyimmunity
  • 【文献出处】 中国兽药杂志 ,Chinese Journal of Veterinary Drug , 编辑部邮箱 ,2002年08期
  • 【分类号】S859.797
  • 【被引频次】11
  • 【下载频次】281
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