【摘要】 2组健康艾维因肉鸡各 8只 ,体重 (1.6 6± 0 .11) kg,研究了对其单剂量 (10 mg/kg,以沙拉沙星碱计 )静注和口服盐酸沙拉沙星后的药动学及其生物利用度 ,用高效液相色谱法测定血清中沙拉沙星的浓度。结果表明 :静注盐酸沙拉沙星溶液后 ,血清药物浓度经时过程符合无吸收因素二室模型 ,其消除半衰期 (t1 / 2β)、总体清除率 (CLB)、表观分布容积 (Vd)和药时曲线下面积 (AU C)分别为 (2 .6 78± 0 .5 0 6 ) h、(1.339± 0 .35 1) L/kg· h、(5 .15 9± 1.5 5 4) L/kg和(7.85 3± 1.731) mg/L· h;口服盐酸沙拉沙星片后 ,药时数据呈有吸收因素一室模型 ,其吸收和消除半衰期 (t1 / 2 ka,t1 / 2 ke)、血清峰浓度 (Cmax)、达峰时间 (Tmax)和药时曲线下面积 (AUC)分别为 (0 .2 87± 0 .117) h、(5 .381± 1.44 6 ) h、(0 .478± 0 .196 ) mg/L、(1.2 2 9± 0 .439) h和 (4 .0 6 0± 1.178) m g/L· h,生物利用度为 (5 1.70± 15 .0 0 ) %。更多还原

【Abstract】 The pharmacokinetics and bioavailability of sarafloxacin hydrochloride,following intravenous and oral administration of single dose 10 mg sarafloxacin/kg,were determined in 8 healthy chickens weighing 1.66±0.11) kg(mean±s),respectively.The serum concentration of sarafloxacin was measured by HPLC method.Pharmacokinetic parameters were obtained by computer calculation.The results showed that:the serum concentration-time date of sarafloxacin were fitted with a two-compartment model for intravenous administration.The elimination hafe-life(t 1/2β),the total body clearance(CL B),the volume of distribution(V d) and the area under the curve(AUC),were 2.678±0.506 h,1.339±0.351 L/kg·h,5.159±1.554 L/kg and 7.853±1.731 mg/L·h,respectively.Following oral administration,the drug concentration-time best described by a one-compartment absorption open model,the absorption and elimination half-lives (t 1/2ka?t 1/ke),the peak serum concentration (C max) and the time to reach C max(T max) were 0.287±0.117 h,5.381±1.446 h,0.478±0.196 mg/L ,1.229±0.439 h and 4.060±1.178 mg/L·h,respectively.The bioavailability(F) ranged from 31.83 to 69.90 (51.70±15.00%)?更多还原