【摘要】 本研究建议了一种数学模型来研究皮肤外层氧的输运特性 ,它包括表皮和真皮乳头中的各个组织层及微循环。特别针对外界为一个标准大气压的空气和外界无氧两种情况下氧分压的变化特性进行了分析研究。文中进一步对血流速度发生变化时所引发的皮肤微循环非稳态演化过程进行了初步探讨。研究结果表明 ,在正常生理条件下 ,皮肤从空气中通过扩散输运所获取的氧仅限于表皮角化层 ,而不能到达表皮生发层。我们还认识到 ,微血管中血流率影响了皮肤组织的氧输运 ,同时微血管环的逆流结构促进了氧从微血管到皮肤组织的扩散输运。更多还原

【Abstract】 We have developed a theoretical model including different tissue layers and microcirculation in epidermis and dermal papillae to investigate the transport of oxygen in outer layers of skin. Oxygen partial pressure PO 2, was simulated under a number of steady and unsteady states when flow rates in capillaries were allowed to remain constant or to increase or decrease. Results from our model revealed that oxygen uptake by diffusion from the air, under normal conditions, was limited to the out most layer of the skin and did not penetrate beyond the germinal layer. Blood flow rate in microvessels affected oxygen delivery to skin and the countercurrent arrangement of papillary loops facilitated oxygen transport from circulation to skin tissue.更多还原