【摘要】 苯乙烯类染料 (Styryldyes) ,如FM 1 4 3和FM 2 10等是近年来发展和广泛应用于突触囊泡循环及突触传递研究领域的一类工具药。这类化合物特异性地标记突触囊泡 ,发出荧光 ,而又不影响囊泡的活性和运转。因此在突触事件中依照荧光强度的变化就可以推断相应的神经胞吞及胞吐的程度 ,跟踪囊泡循环过程。一些突触事件的具体环节 ,在应用了苯乙烯类染料之后 ,得到了进一步的阐明。本文简要介绍苯乙烯类染料的性质和近年来在突触事件研究中的一些主要应用及进展。更多还原

【Abstract】 Styryl dyes, such as FM1 43 and FM2 10, have been widely used in studying synaptic vesicle recycling and synaptic transmission as useful tools in the latest years. They specifically label recycling vesicles and give out fluorescence with the minimum interference to the vesicles’ activity and trafficking. According to the fluorescent information, we can deduce the extent of exocytosis and endocytosis, tracing the recycling process. Some details in synaptic vesicle recycling have been illuminated since the use of styryl dyes. This review will focus on the properties of styryl dyes as well as the studies and the major process in synaptic vesicle recycling that have been made by using of styryl dyes. \[更多还原