【摘要】 目的：观察异丙酚、咪唑安定对急性心肌梗死大鼠血液动力学、心肌梗死范围和心肌超微结构的影响差异。方法：将急性心肌梗死大鼠随机分为对照组（C）、异丙酚组（P1～P4）、咪唑安定组（M1～M4）。测定输注异丙酚30min时的血药浓度，观察血液动力学、心肌梗死范围和心肌超微结构的变化。结果：当异丙酚血药浓度为(3.4±0.9)～(12.9±2.4)μg/ml，MAP、HR、LVSP、±dp/dtmax、Omcci均呈剂量依赖性下降（P<0.05），其下降程度明显大于等效剂量的咪唑安定。各组心肌梗死面积、心肌超微结构无显著性差异(P>0.05)。结论：咪唑安定对心血管系统的抑制轻于等效剂量的异丙酚。更多还原

【Abstract】 Objective: Haemodynamics, myocardial infarction size, ultrastructure of myocardial tissue following infusion with propofol and midazolam have been compared in rats with acute myocardial infarction. Methods: Seventy-two Wistar rats with acute myocardial infarction were randomly divided into 9 groups, with group I as control(C) , the other rats infused with 30（P1）, 45（P2）, 60（P3）, 75（P4）mg/kg/h of propofol and 45 (M1), 67.5(M2), 90(M3), 112.5(M4) mg/kg/h of midazolam for 30 minutes, respectively. After 30 minutes infusion , the haemodynamic changes and ultrastructure of myocardial tissues were observed，and plasmas concentration of propofol and myocardial infarction size were measured. Results: At the average plasma concentration of propofol at the range of (3.4±0.9～12.9±2.4)μg/ml，it caused a greater decrease in the mean arterial pressure(MAP), the heart rate (HR), the left ventricular systolic pressure (LVSP), the maxium and minimum first derivative of left ventricular(LV±dp/dt max) and cardial oxygen consumpution index (Omcci) than equipotent midazolam（P<0.05）, But the left ventricular end-diastolic pressure (LVEDP) had no significant changes in all rats (P>0.05). Myocardial infarction size in propofol group and midazolam group were23.7%~29.2% and 24.3%~28.9% respectively. There were no significant changes in myocardial infarction size and ultrastructure of myocardial tissue (P>0.05). Conclusion: Midazolam may be less depressant to cardiovascular system than propofol in the rat with acute myocardial infarction. There are no significant changes in myocardial infarction size and ultrastructure of myocardial tissue in all groups.更多还原