【摘要】 目的:探讨大样本的型糖尿病患者糖尿病肾病的危险因素,为糖尿病肾病的临床防治工作提供参考意见。2方法:问卷式调查糖尿病病程、高血压家族史,测定糖尿病患者动态血压、心率功率谱、24hHbA1、血、血脂及尿白蛋白排泄cNO率()等,将糖尿病患者分为糖尿病对照组和糖尿病肾病组,比较两组间各因素的差异,分析各因素与的关系。UAERUAER结果:糖尿病肾病组平均血压、病程、高血压家族史、胆固醇()较糖尿病对照组显著增加,及自主神经功能24hTCNO(,)显著低于对照组(PHVPVVP<),且血压、病程、、、、均与密切相关0.05NOPHVPVVTCUAER(P<;多元逐0.05)步回归分析显示血压、病程、自主神经功能是作用于的主要因素。UAER结论:糖尿病肾病是长期代谢紊乱、血压升高和血液流变学异常、自主神经病变及遗传易感等多因素作用的结果,其中,病程长、血压升高、伴有自主神经病变的患者更易出现糖尿病肾脏损害,因此应早期采取综合性的防治措施。更多还原

【Abstract】 Objective: To study the correlated risk factors about diabetic nephropathy of type 2 diabetes. Methods:、 To investigate diabetes durationfamily hypertention history with questionnaire, determine the 24-hour ambulatory blood pressure , heart rate power spectrum, HbA1c, serum nitric oxide(NO), plasma lipids and urinary albumin excretionrate (UAER). The patients were divided into diabetic control group and diabetic nephropathy group. To compare the difference among these factors between the two groups and analyze the relationship of these factors and UAER. Results:、、 The 24-hour mean blood pressurediabetes duration family hypertention history, total cholesterol in diabetic nephropathy group were significantly higher than diabetic control group. NO and autonomic nerve function were lower than that of diabetic control. Furthermore ,these factors were correlated with UAER. Conclusion: Diabetic nephropathy is the result of multiple factors, such as metabolic disorder, blood pressure elevation, abnormal hemorheology, genetic factor etc, among these blood pressure, diabetes duration and autonomic neuropathy are the main factors to impact on UAER, so the comprehensive prevention actions should be taken to diabetic nephropathy.更多还原