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药物贮存期的热分析动力学

Thermal Analysis Study for Prediction of Drugs Shelf-Time

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【作者】 陈栋华唐万军李丽清潘彩霞

【Author】 Chen Donghua Tang Wanjun Li Liqing Pan Caixia Prof, College of Chem and Life Science, SCUFN, Wuhan 430074

【机构】 中南民族大学化学与生命科学学院武汉大学化学与分子科学学院中南民族大学化学与生命科学学院

【摘要】 目的 :研究了药物的热稳定性 ,快速、科学、经济地预测药物的有效贮存期 .方法 :用 TG- DTG热重法测定药物的热降解曲线 ,用 Coats- Redfern积分法求算出热降解反应为一级反应时的动力学参数活化能 E和指前因子A,根据所得到的动力学参数求算出药物在贮存温度—室温 (2 5℃ )下降解反应速率常数 k,进一步探讨药物已知有效期与反应速率常数 k的负对数 pk的相关性 .结果 :市售药物有效期与热分析动力学方法求算得到的 (室温 2 5℃ )pk存在相关性 ,根据市售药物贮存期可将药物室温 (2 5℃ )下 pk划分为 3个区间 :药品的有效期在 1.5 a或 2 a,定为区间 ,pk<7.5 ;药品的有效期为 3a,定为区间 ,7.5 <pk<11;药品的有效期为 4 a或 5 a,定为区间 ,pk>10 .5 .结论 :根据室温 (2 5℃ )下降解反应速率常数 k和药物有效期的相关性 ,通过热分析动力学求算法可初步预测未知药物贮存期 .

【Abstract】 Aim:to study the thermal stabilities of drugs and to predict the shelf time of drugs quickly, scientifically, economically. Methods:thermogravimetry (TG) and differential thermogravimetry (DTG) technique were used to determine the thermal decomposition curves of drugs, and Coats Redfern integral method was used to calculate activation energy E and pre exponential factor A under 1th order reaction model. The decomposition velocity constant k at room temperature was calculated with obtained kinetics parameters. The correlation between decomposition velocity constant k and shelf times of some known drugs was further discussed. Results:there existed correlation between decomposition velocity constant k and shelf time. The values of p k , which were calculated, was divided into three sectors according to shelf times. When p k <7.5 insector Ⅰ, shelf time was 1.5 or 2 years; when 7.5<p k <11 in sector Ⅱ the shelf time was 3 years; and shelf time was 4 or 5 years when p k >10.5 in sector Ⅲ. Conclusion:according to the correlation between decomposition velocity constant k and shelf time of drugs, a simple method was suggested to predict shelf times of some unknown drugs by means of thermal analysis kinetics calculation.

【基金】 湖北省自然科学基金重点资助项目 (2 0 0 1ABA0 0 9)
  • 【文献出处】 中南民族大学学报(自然科学版) ,Journal of South-central College For Nationalities(Natural Sciences) , 编辑部邮箱 ,2002年04期
  • 【分类号】R927
  • 【被引频次】34
  • 【下载频次】433
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