【摘要】 目的 :探讨成人喉乳头状瘤及其癌变中的层黏蛋白 L aminin(L N)和 型胶原 (C )的表达与其生物学特性的关系。方法 :采用免疫组织化学 S- P法检测 10例喉息肉、2 3例喉乳头状瘤、12例喉乳头状瘤恶变组织中 L N、C 的表达。结果 :L N、C 的表达在喉息肉、喉乳头状瘤及癌变各组间均有显著性差异 ,其表达强度在有无淋巴结转移组间亦有明显差异。 3年以上生存组 L N、C 的表达明显高于 0 .5年内死亡组 (P<0 .0 1)。结论 :L N、C 的表达与组织分化和淋巴结转移有关 ,L N、C 的表达可作为评估喉乳头状瘤是否有癌变潜能及癌变者预后的指标更多还原

【Abstract】 Objective:To study the relationship between the expression of laminin and collagen type Ⅳ in laryngeal papilloma with tumor biologic characterization.Methods:The expressions of CⅣ and LN were studied by immunohistochemical techniques (S P) in 10 patients with laryngeal polyp,23 with papilloma and 12 with squamous cell carcinoma.Results:The expressions of LN and CⅣ were significantly different among laryngeal polyp,papilloma and squamous cell carcinoma.The expression of LN and CⅣ were significantly different from the two groups between carcinoma with lymph node positive and negative ones ( P <0.05).The expression of LN and CⅣ were higher in 3 years living groups than 0.5 year dying one.Conclusion:There were relation between the expression of LN,CⅣ and lymph node metastasis.The expression of LN,CⅣ in judge whether laryngeal papilloma can or not change to malignant is a valuable parameter.更多还原