【摘要】 目的　探讨环氧合酶 2 (COX 2 )对胃癌血管内皮生长因子 (VEGF)的表达及血管生成的影响。方法　应用免疫组织化学技术检测胃癌组织中COX 2 ,VEGF表达和微血管密度 (MVD)。结果　COX 2在62 .2 %胃癌组织中表达增高 ,COX 2表达与VEGF表达显著相关 (γS=0 .5 85 ,P <0 .0 1 ) ,且COX 2和VEGF均阳性的胃癌组织MVD(64.0± 2 5 .4)亦明显高于两者均阴性者 (3 0 .7± 1 1 .5 ) (P <0 .0 1 )。结论　胃癌组织中存在COX 2的高表达 ,COX 2通过增加VEGF表达而促进肿瘤血管形成更多还原

【Abstract】 Objective To investigate the effects of COX\|2 expression on vascular endothelial growth factor (VEGF) and angiogenesis in gastric carcinoma.Methods The expression of COX\|2, VEGF and microvascular density (MVD) was examined by immunohistochemical staining.Results COX\|2 expression was detected in 62.2% of gastric carcinoma;The expression of COX\|2 was significantly correlated with VEGF ( P <0.01);Increased expression of COX\|2 and VEGF was significantly correlated with an increase in MVD ( P <0.01).Conclusion COX\|2 overexpression was found in gastric carcinoma, COX\|2 may stimulate angiogenesis through VEGF upregulation.更多还原