【摘要】 通过头孢他啶间断腹腔注射及连续腹腔滴注两种给药方式 ,观察了该药对大鼠肺炎克雷伯氏菌肺炎的疗效。结果显示 ,两种给药方式产生类似的治疗效果 ,但连续给药的 ED50 显著低于间断给药的 ED50 ,而且连续给药方式所产生的血药浓度维持时间更长。提示头孢他啶治疗肺炎克雷伯氏菌肺炎时 ,连续给药方式优于间断给药更多还原

【Abstract】 By comparing the therapeutic efficacy of continuous intraperitoneal infusion and intermittent intraperitoneal infusion, ceftazidime on the pneumonia infected by Klebsiella pneumoniae in the rats were studied. Results showed that the effects of the two kinds of intraperitoneal administration were the same, but the ED 50 of the continous intraperitoneal infusion was lower than that of the intermittent intraperitoneal administration. The high level of blood concentration of ceftazidime in the continuous administration can be kept a long time while that in the intermittent group cannot. The results suggested that the continuous intraperitoneal administration of ceftazidime appears to be more effective in the treatment of pneumonia in rats infected by Klebsiella pneumoniae.更多还原