【摘要】 目的 探讨一氧化氮、氧化、脂质过氧化与老年脑梗死的关系及其临床意义。方法 检测了106例老年急性脑梗死患者治疗前后和100例健康老年人的血浆一氧化氮(P-NO)、维生素C(P -VC)、维生素E(P -VE)、β-胡萝卜素(P - β-C)和过氧化脂质(P -LPO)含量及红细胞过氧化脂质(E -LPO)含量并作分析比较。结果 与对照组比较 ,患者组治疗前P-NO、P -LPO、E-LPO含量均升高(均P<0.01),P-VC、P-VE、P- β-C均降低(均P<0.01)。与治疗前比较 ,患者组治疗后P -NO、P-LPO、E -LPO含量均降低(P<0.01～0.05),P -VC、P -VE、P - β-C含量均升高(P<0.01～0.05) ,但与对照组比较情况则同治疗前类似。 结论 老年脑梗死患者体内NO代谢异常 ,一系列自由基连锁反应病理性加剧 ,氧化抗氧化平衡失调 ,氧化和脂质过氧化损伤加剧。更多还原

【Abstract】 Objective To investigate the relationship between cerebral infarction and oxidative/antioxidative indexes in elderly patients and to explore its clinical significance .Methods Plasma nitric oxide (P-NO),Vitamin C(P-VC),Vitamin E(P-VE),β-carotene(P-β-C),lipoperoxides(P-LPO) and erythrocyte lipoperoxides(E-LPO) in 106 patients with senile cerebral infarction (SCI) were determined by spectrophotometric assays before and after treatment (Pre-and post-treatment groups).The same indexes were also measured in 100 healthy senile volunteers (control group). Results Compared with the control group,the mean values of P-NO?P-LPO?E-LPO in pre-treatment group were significantly higher (P<0.01),while P-VC?P-VE and P-β-C were significantly lower (P<0.01).Compared with the pre-treatment group,the mean values of P-NO?P-LPO?E-LPO in the post- treatment group was significantly decreased(P<0.01～0.05), and P-VC?P-VE?P-β-C were significantly increased (P<0.01～0.05).Conclusion The metabolism of nitric oxide in patients with cerebral infarction was abnormal,a series of free radical chain reactions were pathologically aggravated,the balance between oxidation and antioxidation seriously disturbed,and the injuries induced by oxidation and lipoperoxidation intensified.更多还原