【摘要】 目的 :了解乙肝患者肝功能、乙肝五项及HBVDNA的变化及其相关性。方法 :收集门诊患者血清标本 ,同时检测肝功能、HBVELISA和HBVDNA三个不同水平。结果 :在收集的2 5 0 0例标本中 ,肝功能异常率为 6 2 .8% ,HBs -Ag阳性率为 71.2 % ,HBVDNA定量阳性率为 90 .4 %。当病毒拷贝数在 10 5～ 10 6之间时 ,肝功能异常率为 4 .2 85 % ,HBV拷贝数增加肝功能也不同程度加重 ;HBs -Ag阴性的标本中 ,FQ -PCR检出率为 30 .5 6 % ;单独HBs -Ab阳性的FQ -PCR检测的阳性率为 2 2 .35 %。结论 :HBVDNA的FQ -PCR是目前检测乙肝最为敏感的方法更多还原

【Abstract】 Objective:To study the relationship among liver fuction ,five immunological markers and HBVDNA change of patients with hepatitis B. Method: the serum sample of patients were collected and detected three indexes , including liver fuction,HBV ELISA and HBVDNA. Result:Among the 2500 samples,abnormal rate of liver function was 62.8%, positive rate of HBs-Ag was 71.2%,and positive rate of HBVDNA is 90.4%. Abnormal rate of liver fuction was 4.285% when HBV copies was between10 5～10 6, and liver funtion worsened with HBV copies increasing ;About the negtive samples, positive rate of FQ-PCR was 30.56%; In the single HBs- Ab positive samples, positive rate of FQ-PCR was 22.35%.Conclusion: At present ,FQ-PCR is the mor sensitive and specifical methed to test HBV infection. [更多还原