【摘要】 目的　应用数字减影脑血管造影 (DSA) ,研究重组链激酶 (rSK)治疗幼猪急性脑栓塞的疗效。方法　幼猪 4 8头 ,随机分为对照组和 7个rSK组 (剂量 0 5～ 10万IU/kg) ;经颈内动脉注入体外血栓 ,建立幼猪急性脑栓塞动物模型 ;4h后静脉应用rSK ,对照组用安慰剂。治疗结束后 30、6 0、90min复查DSA。结果　随着rSK剂量增大和观察时间延长 ,DSA血管再通率升高 ;rSK 2万IU/kg或以上剂量组的血管再通率均大于对照组 (P <0 0 5 )。结论　静脉用rSK溶化脑血栓有明显量效关系 ,最低有效剂量为 2万IU/kg。更多还原

【Abstract】 Objective Study the thrombolytic efficacy of recombinant streptokinase(rSK) in a swine acute thromboembolic stroke model. Method 48 swines were divided into 7 rSK intravenous thrombolysis groups (dosage from 5 000 to 100 000 IU/kg) and a control group, 6 swines were available for each group. rSK in different dosages were used through abdominal venous catheter respectively after the distal part of ICA had been embolized for 4 hours. Digital substraction angiograms were obtained after administration for 30,60,90 minutes. Result With increase of rSK dosage and extension of observing time, reopening rate of obstructed vessels rised. Reopening rate of obstructed vessels for intravenous thrombolysis groups who suffered from rSK at 20 000 IU/kg or more was higher than that for control group (P<0.05). Conclusion There were time-response and dose-response relationships when the cerebral infarction swine were treated with rSK. It was indicated that the lowest effective dosage was 20 000 IU/kg.更多还原