【摘要】 目的　分析眼部感染的真菌菌属分布与变化。方法　对首都医科大学北京同仁眼科中心 1989～ 2 0 0 0年送检的 2 6 0 9份眼部真菌标本进行培养 ,并对真菌培养的阳性率、季节分布、菌属分布及其变化进行回顾性分析。结果　 2 6 0 9份眼部真菌培养标本中 ,真菌培养阳性 775株 (2 9 70 % )。其中角膜标本 70 7株 (91 2 2 % ) ,结膜标本 2 2株 (2 84 % ) ,前房标本 15株 (1 94 % ) ,玻璃体标本 9株(1 16 % ) ,泪囊标本 3株 (0 39% ) ,其他 19株 (2 4 5 % )。培养阳性菌株季节特点 :1～ 6月份共培养出2 4 9株 (32 13% ) ,7～ 12月份培养出 5 2 6株 (6 7 87% ) ,两者比约 1∶2 1。主要培养阳性菌属为镰刀菌属 ,共 4 5 5株 (5 8 71% )。其中 1989～ 1994年共培养出阳性镰刀菌 96株 ,占总检出菌数的 5 3 6 3% ;1995～ 2 0 0 0年共培养出 35 9株 ,占总检出菌数的 6 0 2 3% ,后 6年较前 6年增加了 6 6 0 %。其次为曲霉菌属 ,共 130株 (16 77% ) ,前 6年培养出 4 0株 (2 2 35 % ) ,后 6年 90株 ,占总检出菌数的 15 10 % ,后 6年较前 6年下降 7 2 5 %。结论　镰刀菌属是我国北方地区主要的眼部致病菌属 ,曲霉菌属致病的比例有所下降更多还原

【Abstract】 Objective To review the distribution and shifting trends of fungal culture specimens in Beijing Institute of Ophthalmology Methods Retrospective analyses of the fungal culture positive rate, the distribution and change of isolates were performed on 2 609 specimens during a 12 year period (1989-2000) Results The number of positive cultures was 775 (707 from the cornea, 91 23%; 22 from the conjunctiva, 2 84%; 15 from anterior chamber, 1 94%; 9 from the vitreous body, 1 16%; 3 from lacrimal sac, 0 39% and 19 from other parts of eye, 2 45%) The average culture positive rate was 29 70% The average ratio of the positive cultures between the first half (from January to June) and the second half (from July to December) of the years was 1∶2 1 The main genus cultured was Fusarium (58 71%), next was Aspergillus (16 8%) The percentage of Fusarium was increased (53 63% from 1989 through 1994 to 60 23% from 1995 through 2000), and the percentage Aspergillus was decreased (22 35% from 1989 through 1994 to 15 10% from 1995 through 2000) Conclusions The Fusaruim is the predominant pathogens of ocular fungal infection in the northern part of China, its frequency was increased during this 12 year period, and meanwhile the frequency of the Aspergillus was decreased It is very important to comprehend the distribution and shifting trends of pathogenic fungi continuously for diagnosis, prevention and treatment of fungal infectious ocular disease更多还原