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中国布依族、苗族人群线粒体DNA Region V区的遗传多态性

Polymorphism of mitochondrial DNA region V in Bouyei people and Miao people living in Guizhou province of China

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【作者】 李永念左丽柯越海陈阿英舒莉萍任玮

【Author】 LI Yongnian 1, ZUO Li 1, KE Yuehai 2, CHENG Aying 1, SHU Liping 1, REN Wei 1 1(Department of Immunology, Guiyang Medical College,Guiyang, Guizhou, 550001 P. R. China. ); 2(Research Institute of Genetics, Fudan University, Shanghai, 200433

【机构】 贵阳医学院免疫学教研室复旦大学遗传学研究所贵阳医学院免疫学教研室 550004550004

【摘要】 目的 研究中国布依族、苗族人群线粒体 DNA Region V区的遗传多态性。方法 采用 PCR直接测序法对布依族 (96份 )及苗族人 (90份 )样本线粒体 DNA Region V区进行序列分析。结果 在布依族及苗族样本中只发现标准型和短型两种多态 ,短型多态 (即 9bp缺失 )频率在布依族、苗族人群中分别为31.1%和 33.3%。结论 中国布依族、苗族人群线粒体 DNA Region V区有相似的多态性 ,而与其他民族或人种有一定差异。

【Abstract】 Objective To investigate the polymorphism of mitochondrial DNA region V in Bouyei people and Miao people living in Guizhou province of China. Methods Polymerase chain reaction and direct sequencing were used in the study. Results Only two kinds of polymorphism were found in Bouyei and Miao people. One was standard pattern, the other short pattern. And the frequencies of short pattern(9 bp deletion) in Bouyei and Miao people were 31.1% and 33.3% respectively. Conclusion The polymorphisms of mitochondrial DNA region V in Bouyei people and Miao people living in Guizhou province of China are similar, but they are different from those in other people.

【基金】 国家人类基因组南方研究中心资助~~
  • 【文献出处】 中华医学遗传学杂志 ,Chinese Journal of Medical Genetics , 编辑部邮箱 ,2002年02期
  • 【分类号】R394
  • 【被引频次】12
  • 【下载频次】104
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