【摘要】 目的　探讨中国人群胰岛素抵抗与心血管病危险因素个体聚集性之间的关系。方法　对北京石景山地区农民、首都钢铁公司工人共 3 899人 (年龄 35～ 6 4岁 )的空腹胰岛素与空腹血糖、血压、血脂、血尿酸之间的关系进行调查。结果　由低至高胰岛素四等分组的心血管病危险因素个体聚集率分别为 1 8 89%、2 8 0 3%、4 0 2 5 %、4 9 49%(χ2 MH=2 2 7 34 ,P =0 0 0 1 ) ,经多元logistic回归调整年龄、性别、工农、体重指数、吸烟、饮酒等因素后 ,显示第 2、3、4等分组与第 1组比较的优势比(OR)及其 95 %可信区间分别为 1 7(1 4～ 2 2 ) ,3 1 (2 5～ 3 9) ,4 6 (3 7～ 5 7)。结论　在中国人群中胰岛素抵抗与心血管病危险因素个体聚集呈剂量 反应关系 ,随着胰岛素水平的升高 ,个体发生危险因素聚集的风险性逐渐增高更多还原

【Abstract】 Objective To explore the relationship of insulin resistance to the clustering of cardiovascular disease risk factors in Chinese population Methods Associations of fasting serum insulin with fasting serum glucose, lipids, uric acid and blood pressure were investigated in two populations (workers in the Capital Iron and Steel Complex and farmers in Shijingshan district in Beijing,including a total of 3 899 men and women, aged 35～64 years old) The Chi square test was used to examine the difference in rates of clustering of cardiovascular disease risk factors among different quartile groups of serum insulin level Logistic regression analysis was used to estimate the ORs and 95% confidence intervals Results The rates of clustering of cardiovascular disease risk factors from the lowest to the highest quartile of serum insulin were 18 89%, 28 03%, 40 25%, 49 49%, respectively (χ 2 MH =227 34, P =0 001), The ORs and 95% confidence intervals were 1 7(1 4～2 2), 3 1(2 5～3 9), 4 6(3 7～5 7), after adjusting for age , sex, body mass index, smoking, drinking, worker/farmer, etc Conclusion There was a dose response relationship between insulin resistance and the clustering of cardiovascular disease risk factors in Chinese middle aged men and women更多还原