【摘要】 目的　探讨肿瘤体外药敏试验三磷酸腺苷生物发光法 (ATP TCA)在肝癌综合治疗中的应用。方法　取 36例肝癌手术、活检和穿刺标本行ATP TCA。结果　ATP TCA的可评估率为 94.44 % ;1 0种化疗药物的敏感率分别为 :5 氟脲嘧啶 (5 Fu) 8.33 %、诺消灵 (MIT) 8.33 %、顺铂(CDDP) 1 1 .1 1 %、草酸铂 (OXA) 1 3 .89%、足叶已甙 (VP 1 6) 1 9.44 %、丝裂霉素 (MMC) 2 5 .0 0 %、表阿霉素 (EPI) 2 7.78%、开普拓 (CPT) 4 4 .44 %、健择 (GEM) 4 7.2 2 %、泰素 (TAX) 63 .89%。结论　ATP TCA法可用于肝癌化疗中化疗药物的筛选更多还原

【Abstract】 Objective To study the application of the ex vivo ATP tumor chemosensitivity assay (ATP TCA) in the chemotherapy of primary liver cancer.Methods The surgical and biopsied specimens of 36 patients were tested by the ATP TCA.Results Evaluable test results were achieved in 34 of 36 patients with the evaluability being 94.44%.The sensitive rate of 5 Fluoruracil (5 Fu),Mitoxantron (MIT),Cisplatin (CDDP),Oxaliplatin (OXA),Etoposid (VP 16),Mitomycin C (MMC),Epirubicin (EPI),Irinotecan (CPT),Gemcitabine (GEM),Paclitaxl (TAX) was 8.33%,8.33%,11.11%, 13.89%, 19.44%,25.00%,27.78%,44.44%,47.22%,and 63.89% respectively.Conclusion ATP TCA is a choice for the screening of chemotherapeutic drugs against primary liver cancer.更多还原