【摘要】 以 6 ,7,8-三氟 - 1,4 -二氢 - 4 -氧代 - 3-喹啉酸乙酯为原料 ,经氟乙基化、与 N-甲基哌嗪缩合和水解等 3步反应制得氟罗沙星 ,总收率 6 7.5 %。工艺操作简单 ,适于工业生产。更多还原

【Abstract】 Fleroxacin was synthesized from ethyl 6,7,8 trifluoro 1,4 dihydro 4 oxo 3 quinolinecarboxylate via fluoroethylation, condensation with methylpiperazine and hydrolysis in an overall yield of 67.5%. The process was simple and suitable for scale up production.更多还原