【摘要】 苯甲硫醚经傅克乙酰化得对甲硫基苯乙酮 ,于冰醋酸中直接用双氧水氧化得对甲磺酰基苯乙酮 ,无需纯化 ,直接以溴素溴化 ,最后与苯乙酸缩合、环合生成 COX- 2选择性抑制剂罗非昔布。总收率为 5 8%更多还原

【Abstract】 Rofecoxib, a selective COX 2 inhibitor, was synthesized from thioanisole by acetylation, oxidization, bromination, condensation and cyclization with an overall yield of 58%.更多还原