【摘要】 2 ,4-二硝基苯胺经还原反应得到 1,2 ,4-三氨基苯 ,然后经环合、溴化、异硫氰化缩合和环合 ,得到溴莫尼定游离碱。最后再与 L-酒石酸在丙酮中成盐得酒石酸溴莫尼定 ,总收率为 35 %。本法原料易得 ,便于生产。更多还原

【Abstract】 Triaminobenzene, prepared by reduction of 2,4-dinitroaniline, underwent the reaction sequence of cyclization, bromination, isothiocyanation, condensation, cyclization and salt formation with L-tartaric acid to yield brimonidine tartrate in overall yield of 35%.更多还原