【摘要】 目的　探讨男性不育的发病机理。　方法　扫描电镜下观察正常生育男性 4 0个精子 ,不育男性 6 0个精子 ,对精子顶体结构进行对照分析。　结果　不育症精子环状沟模糊者占 6 6 .7%(40 /6 0 ) ,呈锯齿状者占 6 5 .0 % (39/6 0 ) ,而生育精子分别占 10 .0 % (4/40 )和 5 .0 % (2 /40 ) ,两组比较差别有显著性意义 ,P <0 .0 5。不育顶体占头部比例为 (70 .0± 8.0 ) % ,大于正常生育精子的 (5 7.7%± 6 .4 ) % ,P <0 .0 5。顶体膜不完整者不育组占 70 .0 % (42 /6 0 ) ,生育组占 2 2 .5 % (9/40 ) ;表面粗糙者不育组占 6 8.33% (41/6 0 ) ,生育组占 2 0 .0 % (8/40 ) ;表面有颗粒粘附者不育组占 6 5 .0 % (39/6 0 ) ,生育组为 2 7.5 % (11/40 ) ;差别均有显著性意义 ,P <0 .0 1。　结论　精子顶体结构异常是导致男性不育的原因之一。更多还原

【Abstract】 Objective To study the mechanism of male infertility. Methods Forty sperms from 8 normal males as control and 60 sperms from 12 males with infertility were observed by SEM.The ultrastructure of acrosomes was analyzed and compared. Results Spermatozoa with obscure ringed rips in infertile group acounted for 66.7%(40/60),serrate 65.0%(39/60);but in control group,the proportions were 10.0 % (4/40) and 5.0%(2/40),respectively.The ratios of acrosome to head in infertile group were ( 70.0 ±8.0)%,greater than controls (57.7±6.4)%.The ratios of acrosome membrane which was not intact were 70.0%(42/60) in infertile group and 22.5%(9/40) in control group.Acrosomes with rough surface were 68.3%(41/60) and 20.0%(8/40) respectively in the 2 groups;Acrosomes with particles adhesive to the surface were 65.0%(39/60) and 27.5%(11/40) respectively. Conclusions Abnormal acrosome structure is one of the causes of male infertility.更多还原