【摘要】 目的　研究新疆环境补碘新方法对婴儿死亡和儿童发育的影响。方法　用补碘前和补碘后 2乡历年 5岁儿童尿碘、身高和头围监测资料 ,以美国同龄儿童为参照计算Z得分。用logistic回归方法分析 4乡 3县 1988～ 1999年的婴儿死亡和新生儿死亡数据。结果　环境补碘后婴儿死亡相对风险比降低了 5 6 .4 9% ,新生儿死亡相对风险比降低了 6 5 .71% ;控制是否补碘变量后 ,实验区和对照区婴儿死亡或新生儿死亡差异无显著性。朗如乡 5岁儿童平均身高由 1992年的 95cm提高到 1998～1999年的 10 6 .9cm ;同期平均头围由 4 8.4cm提高到 5 0 .5cm ;尿碘中位值由补碘前低于 10 μg/L提高到 176 μg/L。巴克其乡 5岁儿童平均身高由 1993年的 91cm提高到 1998～ 1999年的 10 6 .5cm ;同期平均头围由 4 8.7cm提高到 4 9.6cm ;尿碘中位值由 39μg/L提高到 138μg/L。结论　新疆和田地区的环境补碘方法显著地降低了婴儿、新生儿死亡率 ,极大地改善了儿童的生长发育状况。更多还原

【Abstract】 Objective To study the effect of iodine supplementation on infant mortality and growth in Xinjiang. Methods Urine iodine, height and head circumference (HC) of children aged 5 years in two townships was measured before and yearly after iodine supplementation of irrigation water. Height and HC were expressed as Z scores (United States children used as the reference group). Neonatal and infant mortality rates were obtained from official records in three counties from 1988 to 1999, and analyzed by a logistic regression model. Results The odds ratio of infant mortality decreased 56.49 % and neonatal mortality 65.71 % respectively after iodination; there was no significant difference in the odds ratio of infant or neonatal mortality between experimental and control areas without iodination. In Langru township, the mean height of 5 year old children increased from 95 cm in 1992 to 106.9 cm in 1998 1999, and HC from 48.4 cm to 50.5 cm. Median urine iodine increased from <10 to 176 μg/L. In Bakechi township, mean height increased from 91 cm in 1993 to 106.5 cm in 1998 1999, HC from 48.7 to 49.6 cm, and median urine iodine from 39 to 138 μg/L. Conclusion In Xinjiang, adequate iodine treatment markedly decreased infant and neonatal mortality, and largely preventing stunting of height and HC in children.更多还原