【摘要】 目的　评价超高分子量聚DL乳酸板状植入物植入生物体内后 ,聚DL乳酸及其降解产物的生物相容性。方法　将超高分子量聚DL乳酸板植入SD大鼠下颌升枝与嚼肌之间 ,在术后 1年内 :①分批采取血液标本 ,检测血红蛋白、蛋白含量、胆红素含量、脂类含量及重要的酶与电解质 ,观察植入物对机体血液成分的影响。②分批处死动物进行大体解剖学、组织病理学检查 ,观察植入物周围组织的变化情况。结果　①在术后 1年各组中 ,血液学各项生理指标均未见异常改变。②植入物在术后 6个月左右基本降解 ;在术后 1年的各组中 ,组织愈合、内脏解剖和局部组织病理检查光镜观察 ,均未见异常发现。结论　超高分子量聚DL乳酸植入物在动物体内生物相容性良好。更多还原

【Abstract】 Objective To evaluate the biocompatibility of the super high molecular weight poly D,L lactic acid (SHMW PDLLA) implant. Methods The SHMW PDLLA plates were implanted into the SD rats between the masseter and ramus of the mandible. The blood specimens were gained at 3, 6, 9, 12 months after the operation. The proteins, electrolyte, enzyme and other indices were tested by use of Beckman automatic biochemical analysis device. The soft tissue specimens around the SHMW PDLLA plates were gained at 3, 6, 9, 12 months after the operation and the tissue reaction was observed with the pathological and haematological methods. Results There were not any abnormal findings in the blood after the SHMW PDLLA plates implanted in the body of SD rats. The implanted SHMW PDLLA plates were degraded gradually in 6 to 12 months after the operation. There was not any abnormal tissue reaction found to the soft tissue around the SHMW PDLLA plates by histological and pathological observations. Conclusions The SHMW PDLLA implant has a good biocompatibility to SD rats.更多还原