【摘要】 目的　探讨肾小球滤过率 (GFR)与多种临床因素的相关关系。方法　用99Tcm DTPA清除率测定 5 0例肾功能正常者和 72例肾功能不全者 (其中原发病为慢性肾炎者 46例 ,其他疾病者 2 6例 )GFR ,同时采血测血清肌酐 (SCr)、尿素氮、尿酸、K+ 、Na+ 、Ca2 + 、血红蛋白 ,并测心率、尿比重、2 4时尿蛋白定量、平均动脉压、体重指数、体表面积 ,记录受检者年龄、测定GFR所用核素剂量。将各组及不同原发病的GFR分别与同组的上述各临床因素进行简单相关分析 ,对与GFR有相关关系的上述临床因素再与GFR作多元相关分析。结果　在肾功能正常、肾功能不全组中 ,GFR均与SCr呈负相关 (r分别为 - 0 .44 9和 - 0 .2 75 ,P均 <0 .0 5 ) ,与其他临床因素的相关关系则各不相同。结论　在肾功能正常及不同原发病引起的肾功能不全者中 ,SCr是反映GFR的理想指标。更多还原

【Abstract】 Objective To investigate the relative correlation between glomerular filtration rate(GFR) and various clinical factors and to offer theory basis for the measurement of GFR by the calculation method. Methods GFR of 50 cases of normal renal function group and 72 cases of renal insufficient group were determined using clearance of 99 Tc m-DTPA, and serum creatinine(SCr). Blood urea nitrogen, uric acid, serum potassium, sodium, calcium and hemoglobin were determined simultaneously; and heart rate, urine specific gravity, 24 h urine protein quantum, average artery pressure, body-weight index and body-surface area were determined simultaneously as well. Age and isotope dose for determining GFR were recorded. The simple correlation analysis of GFR in every group with different primary diseases to every other clinical factor above-mentioned were performed and the multiple correlation analysis of every clinical factor above-mentioned that were significantly correlated with GFR to GFR were performed again. Results For normal renal function group and renal insufficient group, correlation coefficient ( r ) between GFR and SCr were -0.449 and -0.275, respectively ( P<0.05) . The correlations between GFR and other clinical factors were with different trends. Conclusion In renal insufficient patients with different primary diseases and normal renal function subjects the SCr is the ideal index for estimating GFR.更多还原