【摘要】 目的 研究 ＨＢｓＡｇ与β２糖蛋白Ｉ（β２ＧＰ　Ｉ）的结合特性，探讨 β２ＧＰ Ｉ参与 ＨＢＶ感染的机制。方法 采用酶联免疫吸附实验，研究标记的人β２ＧＰ Ｉ与重组ＨＢｓＡｇ的结合特性。结果 标记的人β２ＧＰ Ｉ与ＨＢｓＡｇ有高度亲和力，并可以被过量的未标记人β２ＧＰ Ｉ所抑制。结论 β２ＧＰ Ｉ与ＨＢｓＡｇ的结合特性可能是β２ＧＰ Ｉ介导乙肝病毒感染肝细胞的结构基础。更多还原

【Abstract】 Objective To clarify the binding character betweenβ2-glycoprotein I (β2GPI ) and HBsAg. Methods β2GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg. Results Biotinylatedβ2GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelledβ2GPI. Conclusionsβ2GPI may play a role in hepatitis B virus infection.更多还原