【摘要】 目的　分析前列腺癌放射治疗的疗效及预后因素。方法　回顾分析本院常规放射治疗前列腺癌 4 5例 ,4 1例放射治疗前接受双侧睾丸切除 ,2 9例同时服用内分泌治疗药物。采用常规放射治疗技术 ,5次 /周 ,1.8～ 2 .0Gy/次 ,肿瘤剂量最低 5 0 .4Gy ,最高 75 .9Gy ,中位 6 8.3Gy。结果　中位随访 2 8个月 (范围 1～ 111个月 ) ,随访率 91.1%。 5年总生存率为 76 .4 % ,肿瘤特异生存率为 76 .5 %。1、2、3级急性胃肠道反应发生率分别为 5 3.5 %、7.0 %、9.3% ,1、2级急性泌尿生殖系统反应发生率分别为 4 1.9%、4 .7% ;1、2级胃肠道晚期反应发生率分别为 16 .7%、7.1% ,1、2、3级泌尿生殖系统晚期反应发生率分别为 2 3.8%、4 .8%、2 .4 %。结论　前列腺癌的放射治疗结果较为满意 ,治疗的副反应尚能承受更多还原

【Abstract】 Objective To evaluate the outcome , side effects and prognosis of prostate carcinoma treated with external radiotherapy. Methods From 1990 to 1999, a total of 45 prostate carcinoma patients were treated. Four cases were lost during follow up. Forty one patients underwent orchiectomy before radiation therapy , 29 received orchiectomy combined with hormone treatment. All patients received conventional radiation therapy with a median dose of 68.3 ?Gy (50.4 75.9?Gy), 1.8 2.0?Gy per fraction, five fractions weekly. Results The median follow up duration was 28 months (1 111 months). The overall 5 year survival was 76.4% and the 5 year disease specific survival was 76.5%. In terms of acute GI side effects, the frequencies of Grade Ⅰ, Ⅱ or Ⅲ reactions were 53.5%, 7.0% and 9.3% while Grade Ⅰ or Ⅱ , acute GU side effects were 41.9% and 4.7%, respectively. For the long term deleterious effects,Grade Ⅰ or Ⅱ in GI late complications were 16.7% and 7.1% and the GU late morbidities of Grade Ⅰ,Ⅱ or Ⅲ were 23.8%, 4.8% and 2.4%, respectively. Regional lymph node metastasis was closely correlated with both overall survival (P= 0.002 ) and disease specific survival (P= 0.002 ). Multivariate analysis revealed, only regional lymph node metastasis was of prognostic value to predict the overall survival and disease specific survival. Conclusion The outcome of radiation therapy for patients with T 2 T 4 prostate carcinoma is satisfactory with the side effects tolerable to most patients.更多还原