【摘要】 目的 :研究人体单剂量口服乙醇后 ,乙醇在体内的毒性代谢产物乙醛在唾液和全血中的浓度 时间变化过程。方法 :采用高效液相色谱荧光法测定 10名健康受试者单剂量口服乙醇 0 .3g·kg-1后 4h内唾液和全血中的乙醛浓度经时过程。结果 :乙醛在唾液中的Cmax(11.5± 2 .2 ) μmol·L-1,AUC(140 2 .7± 44 7.4)min·μmol·L-1;乙醛在全血中的Cmax(1.6 8± 0 .2 5 )μmol·L-1,AUC(176 .8± 41.4)min·μmol·L-1。结论 :服用乙醇后唾液中的乙醛浓度显著高于全血中更多还原

【Abstract】 OBJECTIVE To study the concentration-time procedure of salivary and blood acetaldehyde in individuals following oral ethanol administration, which is the toxic metabolite of ethanol.METHODS Ten volunteers were given an oral acute dose of 0.3 g ethanol·kg -1 body weight. Salivary and blood acetaldehyde concentrations were measured using HPLC with fluorescence detection over a period of 240 min.RESULTS Salivary acetaldehyde C max and AUC were ( 11.5± 2.2) μmol·L -1;and ( 1402.7± 447.4) min·μmol·L -1 respectively; Blood acetaldehyde C max and AUC were 1.68± 0.25 μmol·L -1 and ( 176.8± 41.4) min·μmol·L -1 respectively.CONCLUSION Compared with acetaldehyde concentrations in blood, acetaldehyde concentrations in saliva were significantly higher after ethanol ingestion.更多还原