【摘要】 目的　研究冰片对顺铂 (DDP)透血脑屏障 (BBB)的促进作用。方法　用ICP AES测量给药后KM小鼠和Wistar大鼠脑中Pt2 + 的浓度。结果　冰片对DDP透过BBB具有促进作用。量效实验表明 :冰片对于♂KM小鼠的最佳剂量为 0 .2 5 g·kg-1·d-1;时效实验表明 :经过冰片的促透作用 ,DDP能够以较高浓度在小鼠脑中维持较长时间 ;给药方式的研究表明 :冰片通过ig和iv方式给药均能增加DDP在小鼠脑中的含量。 结论　冰片是一种有前景的、能有效促进DDP透过BBB的抗脑癌助剂更多还原

【Abstract】 OBJECTIVE This paper studied the auxo-action of Borneol in the penetration of cisplatin(DDP) to the blood-brain barrier(BBB).METHODE The ICP-AES was used to detect the concentration of Pt 2+ in the brains of KM mice and Wistar rats.RESULTS Borneol promoted the penetration of DDP to the BBB.The dose-effect relationship showed that the best dosage of borneol to KM mice was 0.25 g·kg -1·d -1.The time-effect relationship showed that higher concentration of DDP in mice brain was held for at least 2 days after the treatment of borneol.The administration study showed that the medication of ig & iv both increased the contents of DDP in mice brain.CONCLUSION Borneol appeared to be a prospecting assisting agent with auxo-action on the penetration of DDP across BBB in the therapeutics of brain cancer.更多还原