【摘要】 目的 :观察大鼠弥漫性脑损伤后血浆中一氧化氮 (NO)及内皮素 (ET 1)含量的变化。方法 :利用Mar marou创立的模型造成大鼠不同程度的弥漫性脑损伤 ,于伤后 6h抽血检测血浆中NO及ET 1含量。结果 :轻、重度弥漫性脑损伤后血浆中NO及ET 1均有明显升高 ,(P <0 .0 5 )。其中轻度损伤后血浆中NO含量从 (2 6 .70±3.30 ) μmol/L升高至 (35 .6 8± 2 .39) μmol/L ,ET 1含量从 (85 .0 7± 2 .89)ng/L升高至 (94 .2 0± 3.4 6 )ng/L。重度弥漫性脑损伤后血浆中NO含量升高至 (46 .86± 4 .1) μmol/L ,ET 1含量升高至 (131.0 4± 9.0 )ng/L。 结论 :NO和ET 1参与弥漫性脑损伤的原发及继发性神经组织损伤的病理过程 ,且二者的血浆浓度与脑损伤程度密切相关。更多还原

【Abstract】 Objective: Our aim was to observe the change of plasma nitric oxide (NO) and endothelin (ET) in rats after diffuse brain injury. Methods: Two groups of rats received mild and heavy diffuse brain injury separately by using the model established by Marmarou A. Six hours after injury, the concerntrations of NO and ET were measured. Results: The concerntrations of NO and ET increased obviously after injury. The concerntration of NO increaed from (26.70± 3.30) μmol/L to (35.68±2.39) μmol/L after mild injury and to (46.86±4.1) μmol/L after heavy injury. The concerntration of ET increased from (85.07±2.89) ng/L to (94.20±3.46) ng/L after mild injury and to (131.04±9.0) ng/L after heavy injury. Conclusion: Both ET and NO take part in the pathophysiologic process of diffuse brain injury, the increased degree of NO and ET is related with the injury degree.更多还原