【摘要】 目的 :探讨滨蒿内酯 (Scop)松弛豚鼠气管平滑肌的机制。方法 :进行豚鼠气管平滑肌细胞分离 ,通过负荷钙离子荧光指示剂fluor 3 AM进行 [Ca2 + ]i 测定。结果 :Scop可直接降低豚鼠气管平滑肌 [Ca2 + ]ii,并且能抑制磷酸组织胺 (His)和咖啡因 (caffeine)对气管平滑肌 [Ca2 + ]i 的升高作用。结论 :Scop松弛豚鼠气管平滑肌的主要作用机制是抑制细胞内钙浓度水平更多还原

【Abstract】 﨩bjective: [WT5"BZ] Our aim was to study the mechanism o f the relaxation effect of scoparone(Scop) on the tracheal smooth muscle(TSM) of guinea pig. [WT5"HZ]Methods: [WT5"BZ]With the help of spectrophotometer, we detected the [Ca 2+ [DK]] ii of the isolated TSM loaded by fluor 3 A M of guinea pig. [WT5"HZ]Results: [WT5"BZ] The Scop directly reduced isolate d TSM [Ca 2+ [DK]] i of guinea pig, and inhibited increase of [Ca 2+ [DK]] i of TSM which was induced by histamine(His) and caffeine. [WT5"HZ]C onclusion: [WT5"BZ]The Scop has dilatory effect on TSM on condition of decrea sing the TSM [Ca 2+ ] i of guinea pig. [WT5"HZ]更多还原