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微紫青霉中的化学成分研究
Studies on the chemical constituents of Penicillium janthinellium Biourge
【摘要】 目的研究微紫青霉代谢产物对稻瘟霉分生孢子和菌丝体的生长抑制作用。方法通过理化性质和光谱数据的分析鉴定结构 ,利用稻瘟霉模型测试活性。结果与结论从微紫青霉代谢产物中分离得到了 4个化合物 ,分别鉴定为 3 (1 甲基乙基 ) 6 (1 甲基丙基 ) 2 ,5 哌嗪二酮 (Ⅰ )、(3S ,8aS) 3 甲基 1,2 ,3 ,4,6,7,8,8a 八氢吡咯骈 [1,2 a] 吡嗪 1,4 二酮 (Ⅱ )、二十二烷酸 (Ⅲ )、2 甲酰基 3 ,5 二羟基 4 甲基苯甲酸 (Ⅳ )。上述 4个化合物均对稻瘟霉分生孢子和菌丝体的生长有一定的抑制作用。
【Abstract】 Objective To study the growth inhibition of conidia of P.oryzae of the metabolites of Penicillium janthinellium Biourge.Methods The four structures were confirmed by the analysis of physical and chemical properties and spectral data.Results and discussion Four compounds were isolated from Penicillium janthinellium Biourge and they were identified as 3 (1 methylethyl) 6 (1 methylpropyl) 2,5 piperazinedione(Ⅰ),(3 S ,8a S ) 3 methyl 1,2,3,4,6,7,8,8a octahydropyrrolo pyrazine 1,4 dione(Ⅱ),docosanoic acid(Ⅲ)and 2 formyl 3,5 dihydroxy 4 methylbenzoic acid(Ⅳ)respectively.All the 4 compounds could inhibit the growth of conidia of P.oryzae.
【Key words】 Pyricularia Oryzae; Penicillium janthinellium; 3 (1 methylethyl) 6 (1 methylpropyl) 2,5 piperazinedione; (3 S ,8a S ) 3 methyl 1,2,3,4,6,7,8,8a octahydropyrrolo pyrazine 1,4 dione; 2 formyl 3,5 dihydroxy 4 methyl benzoic ac;
- 【文献出处】 中国药物化学杂志 ,Chinese Journal of Medicinal Chemistry , 编辑部邮箱 ,2002年04期
- 【分类号】R284
- 【被引频次】12
- 【下载频次】163