【摘要】 以噻吩为原料 ,与甲醛和氯化氢反应制得 2 氯甲基噻吩 ,再经取代和LiAlH4还原得到目标产物 2 (2 噻吩 )乙胺 ,该法合成步骤少 ,反应条件温和 ,总收率可达 70 % ,适合于工业化生产更多还原

【Abstract】 Thiophene,as the starting material,was reacted with formaldehyde and hydrogen chloride to give 2 chloromethylthiophene.The object compound,2 (2 thienyl)ethylamine,was synthesized from 2 chloromethylthiophene via substitution,then reducted by LiAlH 4.The reaction of the three steps were carried out under moderate conditions to afford an overall yield of 70%.The method was more suitable for industrial process.更多还原