【摘要】 目的 采用HPCE法拆分八种含氨基手性药物对映异构体。方法 缓冲液中添加18-冠-6-四甲酸18-Crown-6（COOH）4（18C6H4）,并且对18C6H4的浓度、缓冲液的pH值和浓度以及柱温等影响分离的因素作了系统的研究;检测波长210nm。结果 八种含氨基手性药物对映体得以拆分。结论 缓冲液中添加手性冠醚的 HPCE法能较好地拆分伯胺类药物。更多还原

【Abstract】 AIM Chiral separation of drugs having a primary amino group was studied by high performance capillary electrophoresis(HPCE) using 18C6HA as chiral selector. METHODS Both complexation and resolution were affected by 18C6HA concentration, pH and concentration of electrolyte. The influence of working voltage and capillary temperature on the enantiomeric separation was also investigated. RESULTS Eight enantiomers tested were separated by HPCE. CONCLUSION Chiral separation of amino- drugs by high performance capillary electrophoresis was successful through the addition of a chiral crown ether, 18-crown-6 tetracarboxylic acid (18C6HA).更多还原