节点文献

丹参酮分散片制备工艺研究

Study on the Preparation Technique of Tanshinone Dispersible Tablets

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 胡容峰钱金粉王成永孟浩王家骅

【Author】 HU Rongfeng,WANG Jiahua,QIAN Jinfen,WANG Chengyong,MENG Hao(Dept. of Pharmaceutics, Anhui College of Traditional Chinese Medicine,Hefei 230038)

【机构】 安徽中医学院药剂学教研室皖西师范学院化学系 合肥市 230038合肥市 230038合肥市 230038

【摘要】 目的:探讨丹参酮分散片的制备工艺。方法:采用正交设计法,以崩解时限、体外溶出度及混悬性为指标,对丹参酮分散片处方进行筛选。结果:分散片在30s内完全崩解,均匀性试验能通过710μm筛网,达到《英国药典》(1993年版)关于分散片的要求,体外溶出度明显优于普通片。结论:制备的丹参酮分散片工艺成熟,质量稳定。

【Abstract】 OBJECTIVE: To study the preparation technique of tanshinone dispersible tablets.METHODS: Taking the disintegration time - limit, in vitro dissolubility and suspensibility as indices, the formula of tanshinone dispersible tablets was screened by orthogonal design.RESULTS The dispersible tablets could completely disintegrate within 30 seconds and pass through 710m seive mesh, which all conformed to the requiremtes of BP(1993) .The in vitro dissolubility of this product was superior to that of ordinary tablets obviously .CONCLUSION: The preparation technique of tanshinone dispersible tablets is mature and the quality is reliable.

  • 【分类号】TQ464
  • 【被引频次】15
  • 【下载频次】443
节点文献中: 

本文链接的文献网络图示:

本文的引文网络