【摘要】 目的 :研究聚乳酸的降解性能和制备聚乳酸红霉素微球。方法 :将聚乳酸薄膜置于模拟体液中水解 ,用正交设计优选微球制备工艺。结果 :分子量高的降解比分子量低的慢 ,消旋聚乳酸的降解比左旋聚乳酸的快。微球形态圆整 ,性质稳定 ,平均粒径为(10 98±0 15) μm ,体外释药符合Higuchi方程 (Q=28 067 +3 8515T1/2,r=0 9834)。结论 :聚乳酸的降解与分子量和构型有关 ,微球具有明显的缓释作用和满足肺靶向药物的要求更多还原

【Abstract】 OBJECTIVE:To study the biodegradability of polylactic acid and prepare its microspheres containing erythromycin.METHODS:The polylactic acid film was degraded in vitro.The orthogonal design was used to optimize the technology of preparation of microspheres.RESULTS:The degradable speed of polylactic acid with high molecular weight was faster than that with low molecular weight.The degradable speed of PDLLA was faster than that of PLLA.The microspheres were stable in quality and regular in external form.The average particle size was (10.98±0.15)μm.The in vitro release properties could be expressed by the Higuchi’s equation(Q=28.067+3.8 515 T1/2,r=0.9 834).CONCLUSION:The biodegradability of polylactic acid depended on configuration and molecular weight.Erythromycin microspheres showed significant slow-released property and accorded with the demands of lung targeting agent.更多还原