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银黄酮片的处方优化

Optimization of the Formula of Ginkgo Flavone Tablets

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【作者】 危华玲池泮才卢文胜

【Author】 WEI Hualing,CHI Pancai(Dept.of Pharmacy,The People’s Hospital of Guangxi Zuang Autonomous Region,Nanning 530021)LU Wensheng(Dept.of Pharmacy,The Second People’s Hospital of Nanning,Nanning 530021)

【机构】 广西壮族自治区人民医院药剂科南宁市第二人民医院药剂科 南宁市530021南宁市530021南宁市530021

【摘要】 目的 :筛选银黄酮片的最佳处方。方法 :考察糊精、羧甲基淀粉钠、微晶纤维素和低取代羟丙基纤维素对银黄酮片的质量影响。结果 :筛选的最佳处方为5 %低取代羟丙基纤维素。按照最佳处方制备的银黄酮片崩解度大为提高。结论 :本法处方合理 ,工艺简单 ,所制备的银黄酮片适合临床应用。

【Abstract】 OBJECTIVE:To optimize the formula of Ginkgo flavone tablets.METHODS:The effects of dextrin,CMS-Na,microcrystalline cellulose and L-HPC on the quality of Ginkgo flavone tablets were studied.RESULTS:The results showed that the optimum formula was 5% L-HPC Ginkgo flavone.Tablet prepared with this optimum formula was much better in terms of disintegrantion.CONCLUSION:The formula is reasonable and the preparation technic simple.The prepared tablets are suitable for clinical use.

【关键词】 银杏黄酮片剂崩解度低取代羟丙基纤维素
【Key words】 GinkgoflavonetabletdisintegrantionL-HPC
  • 【分类号】R944
  • 【被引频次】1
  • 【下载频次】126
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