【摘要】 目的　探讨血清瘦素浓度与原发性高血压患者血压水平及靶器官损害、性别、肥胖和脂质代谢的关系。方法　用放射免疫法检测 68例原发性高血压患者和 40例健康自愿者的血清瘦素浓度 ,同时检测甘油三脂 (TG)、总胆固醇 (TC)、高密度脂蛋白 (HDL -C)、低密度脂蛋白 (LDL C)和体重指数 (BMI)等指标 ,分析血清瘦素浓度与不同血压水平和靶器官受累程度不同的原发性高血压以及性别、BMI、血脂的关系。结果　高血压组血清瘦素显著高于对照组(P <0 0 5) ,且 3级高血压血清瘦素显著高于 2级高血压 (P <0 0 5) ,2级高血压血清瘦素显著高于 1级高血压 (P <0 0 5) ,血清瘦素与SBP、DBP均呈直线正相关 (P <0 0 1 ,P <0 0 5) ;血清瘦素浓度与高血压靶器官损害病程度无关 ;女性瘦素显著高于男性 (P <0 0 1 ) ;肥胖者血清瘦素显著高于非肥胖者 (P <0 0 5) ;血清瘦素与TG呈直线正相关 (P<0 0 5) ,而与TC、HDL C和HDL C无关。结论　血清瘦素与血压水平相关 ,与高血压靶器官受损无相关性 ,与性别和TG有关 ,与BMI和TG呈正相关更多还原

【Abstract】 Objective To investigate the relationship among Leptin, primary hypertension, gender, body mass index(BMI)and lipid metabolism. Methods Leptin,TG,TC,HDL C,LDL C and BMI were determined in 40 health persons of control group and 68 patients with primary hypertension. Serum leptin concentration was measured by radioimmunoassay.The correlation between leptin and other parameters were analyzed. Results Leptin levels in primary hypertension was found significantly higher than that in the control group ( P <0 05). Leptin levels in grade 3 hypertension was found significantly higher than that in grade 2 hypertension( P <0 05). Leptin levels in grade 2 hypertension was found significantly higher than that in grade 1 hypertension(P<0 05). Leptin was remarkably correlated with SBP/DBP ( P<0 01/P <0 05). The organ damaged degrees in primary hypertension was not correlated with serum leptin concentration. leptin concentration in female was significantly higher than that in male( P <0 01). Serum leptin level was elevated in obese subjects( P <0 05). Serum leptin concentration was correlated to TG and BMI, but not correlated to TC?HDL C and LDL C. Conclusion Serum leptin concentration is directly related to blood pressure level in patient with primary hypertension, BMI and TG.更多还原