【摘要】 目的　比较长效钙拮抗剂与血管紧张素转换酶抑制剂 (ACEI)单独和联合使用在降压和副作用方面的差异。方法　对 1995年 1月至 1999年 12月间我科单独和联合使用长效二氢吡啶类钙拮抗剂与ACEI降压药治疗的 6 4 5例高血压病患者进行分析。结果　两片钙拮抗剂 (n =15 4 )、两片ACEI(n =2 19)和联合用药 (n =2 72 ,钙拮抗剂和A CEI)三组治疗后血压均明显降低 ,但联合用药组在降收缩压方面最明显 ,而钙拮抗剂组在降舒张压方面最明显。在咳嗽方面 ,ACEI组发生率最高 (2 1% ) ,联合用药组次之 (7% )。在浮肿方面 ,钙拮抗剂组发生率最高 (13% ) ,联合用药组次之 (6 % )。结论　长效二氢吡啶类钙拮抗剂与羧基类ACEI联合用药不仅可增加降压效果 ,而且可减少咳嗽和水肿副作用更多还原

【Abstract】 Aim To compare the antihypertevsive and adverse effect of long acting dihydropyridine calcium antagonists alone and combination with angiotensin converting enzyme inhibitors(ACEI). Methods A case control study was carried out in 645 patients received calcium antagonists alone or combined with ACEI from January 1995 to December 1999 . Results The blood pressure were signifcantly decreased after antihypertensive treatment in ACEI group, ACEI plus calcium antagonist group and calcium antagonists group. The decrease in SBP was most pronounced in ACEI plus calcium antagonist group, while the decrease in DBP was most significant in calcium antagonists group. The prealence of cough was demonstrated in a ACEI dose dependent manner.\ 21% by 20 mg benapril or 8 mg perindopril, 7% by 10 mg benapril or 4 mg perindopril plus one tablet calcium antagonist.\ ( P <0 01). Edema were present 13% of two tablet calcium antagonists group and 6% of ACEI plus one tablet calcium antagonist group ( P <0 05). Conclusion Combination of long acting dihydropyridine calcium antagonists and ACEI has better antihypertensive effect and less adverse reactions.更多还原