【摘要】 目的 :用高分辨力超声检测动脉粥样硬化 (AS)患者的血管内皮功能。方法 :用高分辨力超声检测38例 AS患者和 30例正常对照组肱动脉反应性充血和含服硝酸甘油后变化 ,并测定血浆 NO、ET- 1及血脂水平。结果 :AS组肱动脉血流介导性舒张较对照组明显减弱 [(2 .6 3± 1.5 6 ) %比 (8.2 5± 4 .16 ) % ,P<0 .0 0 1],而两组对硝酸甘油的反应无显著性差异 [(16 .93± 6 .74 ) %比 (2 0 .35± 3.2 1) % ,P>0 .0 5 ]。 AS组血浆 ET- 1较对照组显著升高 ,NO/ ET- 1显著降低 (P<0 .0 1)。血管内皮功能与总胆固醇 (TC)、低密度脂蛋白 (L DL - C)水平均呈负相关关系 (r=- 0 .4 1、 - 0 .6 6 ,P均 <0 .0 1) ,与高密度脂蛋白 (HDL - C)呈正相关 (r=0 .6 2 ,P<0 .0 5 )。结论 :AS患者存在血管内皮依赖性舒张功能障碍 ,超声是评价血管内皮功能简便可靠的方法更多还原

【Abstract】 Objective:To study the endothelium dependent vasodilation function in patients with atherosclerosis.Methods:Thirty eight patients with atherosclerosis and 30 age matched normal controls were studied.Brachial diameter and blood flow velocity were meausred with high resolution ultrasound at rest,during reactive hyperemia and after sublingual nitroglycerin.The plasma NO?ET 1 were measured in all parients.Results:The increased percentage of the brachial artery diameter at hyperemic condition was lower in patients comparing with those of normal controls(2 63±1 56% vs 8 25±4 16%, P <0 001),whereas nitroglycerin induced changes were similar (16 93±6 74% vs 20 35±3 21%, P >0 05)?The plasma level of ET 1 was higher and that of NO/ET 1was significantly lower in atherosclerosis group than that in control group.The brachial endothelial function correlated negatively with TC,LDL C( r =-0 41?-0 66, P <0 01),positively with HDL C( r =0 62, P <0 05).Conclusions:Endothelium dependent vasodilation was impaired in patients with atherosclerosis.It is an accurate and convenient method to evaluate the brachial arterial endothelial function with ultrasonography.更多还原