【摘要】 目的 :本研究旨在通过对冠状动脉造影正常者行冠状动脉内多普勒血流参数的测定 ,研究硝酸甘油和腺苷对冠状动脉血流速度的影响以及硝酸甘油对腺苷测量冠状动脉血流速率储备 (CFVR)有无影响。方法 :对 9例患者 ,冠状动脉造影正常血管 2 4支 (右冠状动脉 9支 ,左前降支 7支 ,左回旋支 8支 )采用多普勒导丝描记血流速度参数 ,经冠状动脉内给予硝酸甘油或腺苷后测量冠状动脉血流速度参数 ,并计算 CFVR。结果 :硝酸甘油和腺苷均加快冠状动脉血流平均峰值流速 (APV,cm/ s) ,分别从 18.5± 4 .0到 2 9.2± 6 .5 ,P<0 .0 0 1和 18.0± 4 .8到 4 4 .5±10 .7,P<0 .0 0 1,硝酸甘油和腺苷组的基础平均峰值流速 (b APV)无差异 ,而充血相平均峰值流速 h APV (cm/ s)有显著差异 (44 .5± 10 .7vs. 2 9.2± 6 .5 ,P<0 .0 0 1)。在用硝酸甘油前后使用腺苷测量的 CFVR没有差异 (2 .5 4±0 .5 7vs2 .4 9± 0 .6 4 ,P=0 .2 93)。结论 :硝酸甘油和腺苷均引起充血反应加快冠状动脉血流速度 ,但腺苷加快冠状动脉血流速度的作用明显强于硝酸甘油 ;用硝酸甘油后对腺苷测量 CFVR无影响更多还原

【Abstract】 Objective:To evaluate the effects of nitroglycerin and adenosine on coronary flow velocity using intracoronary Doppler flow measurement in normal angiographic coronary arteries.Methods:In 24 normal angiographic coronary arteries of 9 patients,coronary artery flow velocity were measured before and after intracoronary nitroglycerin or adenosine administration,the coronary artery flow velocity reserve(CFVR)were calculated.Results:Both nitroglycerin and adenosine accelerate the coronary artery average peak velocity (APV,cm/s)from 18 5±4 0 to 29 2±6 5, P <0 001 and from 18 0±4 8 to 44 5±10 7, P <0 001,respectively).The base APV had no significant difference between the nitroglycerin and adenosine group,but the hyperemia APV(cm/s)has significant difference(44 5±10 7 vs 29 2±6 5, P <0 001).Conclusions:Both nitroglycerin and adenosine induce coronary artery hyperemia response and accelerate coronary artery flow velocity,but the adenosine has more powerful effect than nitroglycerin.更多还原