【摘要】 目的　探讨肺结核患者支气管肺泡灌洗液 (BALF)中T淋巴细胞亚群的特点及其临床意义。方法　采用酶联免疫分析法同时检测 4 8例活动性肺结核及 19例非活动性肺结核患者BALF及外周血中T淋巴细胞亚群。结果　活动性肺结核组BALF及外周血中CD4 T细胞、CD4 /CD8T细胞比值均明显低于非活动性肺结核组 (P <0 .0 1)。活动性肺结核患者BALF中CD8T细胞水平明显高于外周血 (P <0 .0 5 )。空洞性肺结核组BALF及外周血中CD4 /CD8T细胞比值明显低于非空洞组。抗结核治疗 2个月末BALF及外周血中CD4 T细胞、CD4 /CD8T细胞比值均明显升高 ,而BALF中CD8T细胞水平较治疗前降低 (P <0 .0 5 )。结论　BALF及外周血中T淋巴细胞亚群的检测有助于判断病情、了解抗结核治疗效果及预后更多还原

【Abstract】 Objective To assess the characteristic and its clinical value of T lymphocyte subsets in bronchoalveolar lavage fluid(BALF) in patients with pulmonary tuberculosis. Methods T lymphocyte subsets were measured by ELISA assay in BALF and peripheral blood of patients with pulmonary tuberculosis.48 cases were active tuberculosis.19 cases were inactive tuberculosis. Results CD 4 T lymphocytes and CD 4/CD 8 ratios were found in greatly depleted numbers in BALF and peripheral blood in active tuberculosis,there was statistically significant difference when compared with inactive tuberculosis( P <0.01).CD 8 T lymphocytes in active tuberculosis patients were high in BALF than in peripheral blood( P <0.05). CD 4/CD 8 ratios in BALF and peripheral blood were lower in cavitary tuberculosis than non-cavitary tuberculosis. After 2 months’ effective antituberculosis treatments, CD 4 T lymphocytes and CD 4/CD 8 ratios in BALF and peripheral blood showed a significant increase, while CD 8 T lymphocytes in BALF decreased. Conclusion Analysis of T lymphocyte subsets in BALF and peripheral blood was helpful for determining the clinical pattern of disease, recovery situation during treatment and prognosis in patients with pulmonary tuberculosis.更多还原