节点文献

肺结核患者支气管肺泡灌洗液中T淋巴细胞亚群的检测及其临床意义

Detection and its clinical value of T lymphocyte subsets in bronchoalveolar lavage fluid in patients with pulmonary tuberculosis

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 唐神结吴福蓉范以虎李红杨妍何山

【Author】 TANG Shen jie,WU Fu rong,FAN Yi hu,et al.Shanghai Pneumology Hospital,Shanghai 200433

【机构】 上海市肺科医院上海市肺科医院 上海200433上海200433上海200433

【摘要】 目的 探讨肺结核患者支气管肺泡灌洗液 (BALF)中T淋巴细胞亚群的特点及其临床意义。方法 采用酶联免疫分析法同时检测 4 8例活动性肺结核及 19例非活动性肺结核患者BALF及外周血中T淋巴细胞亚群。结果 活动性肺结核组BALF及外周血中CD4 T细胞、CD4 /CD8T细胞比值均明显低于非活动性肺结核组 (P <0 .0 1)。活动性肺结核患者BALF中CD8T细胞水平明显高于外周血 (P <0 .0 5 )。空洞性肺结核组BALF及外周血中CD4 /CD8T细胞比值明显低于非空洞组。抗结核治疗 2个月末BALF及外周血中CD4 T细胞、CD4 /CD8T细胞比值均明显升高 ,而BALF中CD8T细胞水平较治疗前降低 (P <0 .0 5 )。结论 BALF及外周血中T淋巴细胞亚群的检测有助于判断病情、了解抗结核治疗效果及预后

【Abstract】 Objective To assess the characteristic and its clinical value of T lymphocyte subsets in bronchoalveolar lavage fluid(BALF) in patients with pulmonary tuberculosis. Methods T lymphocyte subsets were measured by ELISA assay in BALF and peripheral blood of patients with pulmonary tuberculosis.48 cases were active tuberculosis.19 cases were inactive tuberculosis. Results CD 4 T lymphocytes and CD 4/CD 8 ratios were found in greatly depleted numbers in BALF and peripheral blood in active tuberculosis,there was statistically significant difference when compared with inactive tuberculosis( P <0.01).CD 8 T lymphocytes in active tuberculosis patients were high in BALF than in peripheral blood( P <0.05). CD 4/CD 8 ratios in BALF and peripheral blood were lower in cavitary tuberculosis than non-cavitary tuberculosis. After 2 months’ effective antituberculosis treatments, CD 4 T lymphocytes and CD 4/CD 8 ratios in BALF and peripheral blood showed a significant increase, while CD 8 T lymphocytes in BALF decreased. Conclusion Analysis of T lymphocyte subsets in BALF and peripheral blood was helpful for determining the clinical pattern of disease, recovery situation during treatment and prognosis in patients with pulmonary tuberculosis.

【关键词】 结核,肺T淋巴细胞亚群
【Key words】 Tuberculosis,pulmonaryT lymphocyte subsets
  • 【文献出处】 中国防痨杂志 ,Buccetin of Chinese Antituberculosis Assoclation , 编辑部邮箱 ,2002年05期
  • 【分类号】R521
  • 【被引频次】29
  • 【下载频次】188
节点文献中: 

本文链接的文献网络图示:

本文的引文网络