【摘要】 目的 分析131碘（131I）治疗Graves’病中引起甲状腺功能低下（甲低）的原因。方法 对首次接受131I治疗的Graves’病患者156名随访1年,根据是否发生甲低分为甲低组与非甲低组,用SPSS软件分析治疗前甲状腺质量;3,6,24h甲状腺吸131I率;预计给予每克甲状腺组织的131I实际摄取量;总治疗剂量;治疗前甲状腺激素、TSH水平;是否接受过抗甲药物治疗等参数与甲低发生的关系。结果　131I治疗 1年后,有 80.1％的患者甲状腺功能亢进（甲亢）治愈或明显好转,有6.4％患者仍处于甲亢状态,有15.4％发生了甲低。2组治疗前的甲状腺激素水平及131I总剂量间差异无显著意义,但预计给予每克甲状腺组织的131I摄取量两者间差异有显著意义。结论 早发甲低的发生与甲状腺质量及预计给予每克甲状腺组织的131I剂量有关,治疗前停用抗甲状腺药物>1周以上,131I治疗的疗效不会受影响。更多还原

【Abstract】 Objective The study is retrospective, which is designed to evaluate the influential factors brought into the hypothyroidism. Methods One hundred and fifty-six patiente were divided into two groups according to whether there was hypothyroidism,hypothyroidism and un-hypothyroidism. t test and X2 test were used to compare the variable parameters between the two groups on function、thyroid mass、therapeatic、dosage、uptake and absorbed doses by pergram of thyroid tissue. Results Eighty point one percent were cured or improved, and 15.4% were induced to hypothyroidism after treatment for 1 year. The outcome of treatment depended on the mass of thyroid and the absorbed doses by per gram of thyroid tissue. And pretreatment with thyreostasis did not reduce the therapeutic efficacy of in hypothyroidism if antithyroid drugs were quited for more than weeks before treatment. Conclusions To patients whose thyroid mass is small,we should reduce doses of per gram tissue.更多还原