【摘要】 目的　研究海嘧啶的毒性作用。方法　通过海嘧啶对 FC小鼠和 S1 80 ,H2 2 荷瘤小鼠胸腺和精囊重量及指数的研究 ,观察海嘧啶的毒性作用。结果　海嘧啶可使不同荷瘤小鼠胸腺及精囊萎缩 ,使不同荷瘤小鼠白细胞及血小板数量下降 ,但其萎缩及下降程度均小于 5 - Fu。结论　海嘧啶在毒性方面产生了拮抗作用 ,使 5 - Fu的毒性明显下降 ,即海嘧啶在增强 5 - Fu抗肿瘤作用的同时 ,显著降低了 5 - Fu的毒性。更多还原

【Abstract】 Object To study the toxic action of haimiding. Methods The toxic action of haimiding was tested by measuring the weight and index of thymus gland and seminal vesicle of mice which were transplanted by FC, S 180 and H 22 cells. Results Haimiding can atrophy the thymus gland and seminal vesicle of test mice and reduce the number of leucocyte and platelet, but the extent of atrophy and reduction by haimiding is lower than that by 5 Fu. Conclusion The toxic action of haimiding is obviously lower than that of 5 Fu.更多还原